荀葛博士-实验师
发布时间：2019-10-30 浏览次数：0次
荀葛，女，博士，实验师。2019年6月本科毕业于河北医科大学国际娱乐城 药学专业，2024年6月博士毕业于河北医科大学药物分析学专业，2025年1月入职河北医科大学国际娱乐城 实验中心。研究方向为中药质量控制及药效物质基础研究，主持河北省自然科学基金项目1项，河北省中医药管理局项目1项，参与省、厅级基金项目2项。
科研项目：
1. 主持2025年河北省自然基金面上项目：《基于“成分-代谢-药效-靶点”整合策略的红曲改善脾虚食积证的药效物质与质量评价研究》，项目编号H2025206795，在研。
2. 主持2025年河北中医药管理局课题：《整合多组学与网络药理学的红曲健脾消食功效物质基础及作用机制研究》，项目编号2026100，在研。
代表性论文：
1. Ge Xun, Yingxuan Li, Yifan Zhang, Song Li, Yanhua Gao, Yujuan Chen, Ding Zhang, Hongyang Ni, Fangfang Liu, Yan Fu, Xu Wang*, Qiao Wang**. Integrating untargeted and pseudotargeted metabolomics and network analysis reveals the interventional effects of red yeast rice on rat serum metabolites. Food Bioscience, 2024, 59: 104051.
2. Ge Xun, Yuhuan Tian, Yanhua Gao, Jia Zhang, Xin Liu, Shuo Sun, Qi Qian, Fangfang Liu, Qiao Wang*, Xu Wang**. Identification and comparison of compounds in commercial Tripterygium wilfordii genus preparations with HPLC-QTOF/MS based on molecular networking and multivariate statistical analysis. Journal of Pharmaceutical and Biomedical Analysis, 2022, 216: 114811.
3. Xiaoguang Zhang, Jia Zhang, Ge Xun, Yanhua Gao, Jie Zhao, Yan Fu, Suwen Su, Dezhi Kong, Qiao Wang**, Xu Wang*. Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics. Journal of Ethnopharmacology, 2025, 343: 119485.
4. Shuo Sun, Ge Xun, Jia Zhang, Yanhua Gao, Jiachen Ge, Fangfang Liu, Qi Qian, Xin Liu, Yuhuan Tian, Qian Sun, Qiao Wang*, Xu Wang**. An integrated approach for investigating pharmacodynamic material basis of Lingguizhugan Decoction in the treatment of heart failure. Journal of Ethnopharmacology, 2022, 295:115366.
5. Yanhua Gao, Qi Qian, Ge Xun, Jia Zhang, Shuo Sun, Xin Liu, Fangfang Liu,Jiachen Ge, Huaxing Zhang, Yan Fu, Suwen Su, Xu Wang*, Qiao Wang*. Integrated metabolomics and network analysis reveal changes in lipid metabolisms of tripterygium glycosides tablets in rats with collagen induced arthritis. Computational and Structural Biotechnology Journal, 2023,21:1828-1842.
6. Qi Qian, Yanhua Gao, Ge Xun, Xu Wang, Jiachen Ge, Huaxing Zhang, Feifei Mou, Suwen Su, Qiao Wang. Synchronous Investigation of the Mechanism and Substance Basis of Tripterygium Glycosides Tablets on Anti‑rheumatoid Arthritis and Hepatotoxicity. Applied Biochemistry and Biotechnology, 2022,194(11):5333-5352.
7. 荀葛，张依帆，李映萱，付炎，王巧*。中药药效物质基础研究策略的现状与进展。沈阳药科大学学报,2025,42(05): 412-422.