国际娱乐城

团队负责人：王静（教授，博导）

王静，博士，河北医科大学教授，博士生导师，医学与健康研究院独立PI。现任河北医科大学国际娱乐城 副院长，河北省创新药物研究与评价重点实验室主任，河北省药品监督管理学会药品检验审评监管专业委员会主任委员，河北省毒理学会常务理事。河北省优秀教师，河北省优秀博士、硕士论文指导教师。研究方向集中于纳米药物共晶和纳米材料的生物应用。主持国家自然科学基金2项、中国博士后基金、河北省“高校百名创新人才”支持计划项目、河北省自然科学基金多项、河北省科技厅重大支撑课题、河北省“生物医药联合基金”和“精准医学联合基金”重点项目等多项课题。获河北省科技进步二等奖一项（第一）、三等奖各一项（第一）。以通讯作者在Angewandte Chemie-International Edition, Bioactive Materials, ACS Applied Materials & Interfaces, Food chemistry, Analytical Chemistry, Sensors and Actuators B: Chemical等国内外学术期刊上发表论文多篇。

团队骨干成员：

李蒙（教授，博导），林玉龙（教授，硕导），朱艳艳（教授，硕导），康凯（副教授，博导），韩倩（副教授，硕导），郭伟（副教授，硕导），申燕婷（副教授，硕导），张默（副教授，硕导），张立娜（副教授，硕导），代晓光（讲师），杜思凡（讲师）

研究方向：

1.基于生物活性纳米材料的药物干预体系构建及在肿瘤、阿尔茨海默症、促成骨等疾病中的应用研究。

2.基于功能化纳米材料的新型生物传感器的构建及在监测和检测环境和食品等危害公共健康领域的有害物质、药物、疾病标志物等方面的应用研究。

3.药-药超分子组装（共晶、共无定形、纳米体系）及在肿瘤、糖尿病及相关代谢性疾病等领域的应用。

近五年获批主要科研项目

1.基于自聚集效应的SERS传感平台构建及精准检测食品和环境中抗生素残留新方法研究（82473752），2025/01/01-2028/12/31，国家自然科学基金面上项目，负责人：王静，49万。

2.人工智能辅助高性能光电化学适配体传感器的构建及食品中真菌毒素卫生分析新方法研究（82574221），2026/01/01-2029/12/31，国家自然科学基金面上项目，负责人：康凯，49万。

3.细胞静默区比率型可逆SERS探针的构建及急性肾损伤动态监控研究（22404040）2025/01/01-2027/12/31，国家自然科学基金青年科学基金项目，负责人：申燕婷，30万。

4.多钼氧酸盐@共价有机框架复合物的构筑及抗肿瘤研究（20301060），国家自然科学基金青年科学基金项目，2024/01/01-2026/12/31，负责人：张默，30万。

5.基于单原子Ru/GFs纳米酶“激活”PEC传感平台食品抗生素残留卫生分析新方法研究（82204097），2023/01/01-2025/12/31，国家自然科学基金青年科学基金项目，负责人：朱艳艳，30万。

6.卟啉凝胶限域增强电致化学发光抗生素耐药基因可再生传感器研究（22204040），2023/01/01-2025/12/31，国家自然科学基金青年科学基金项目，负责人：韩倩，30万。

7.新型光电化学生物传感器的构建及超灵敏检测食品中真菌毒素卫生分析新方法研究（82103890），2022/01/01-2024/12/31，国家自然科学基金青年科学基金项目，负责人：康凯，30万。

8.基于Piezo1信号通路精准调控的智能压电聚合物促进骨折愈合及其机制研究（H2025206750），2025/01/01-2027/12/31，河北省精准医学创新发展联合基金，负责人：王静，50万。

9.基于活性代谢产物筛选肾素-血管紧张素-醛固酮/抑制脑啡肽酶双靶点药物及成药性评价（246Z2601G），2024/05/01-2026/4/30，河北省科技厅中央引导地方科技发展资金项目，负责人：王静，50万。

10.无干扰、可逆 SERS 探针的构建及肝缺血再灌注损伤动态监控研究（B2024206003），2024/01/01-2026/12/31，河北省自然科学基金面上项目，负责人：申燕婷，6万。

11.多酸基羟基磷灰石/壳聚糖复合材料多模式联合促进骨折愈合及机制研究（2023TQ0103），2023/01/01-2024/12/31，中国博士后科学基金第73批特别资助（站前），负责人：张默，18万。

12.以激活BMP/Samd信号通路为靶点的多酸基水凝胶复合材料促进骨折愈合研究（2023M730914），2023/01/01-2024/12/31，中国博士后科学基金第73批面上资助一般项目，负责人张默，8万。

13.基于单原子Ru纳米酶的PEC生物传感器构建及超敏C反应蛋白检测新方法研究（H2022206320），2022/01/01-2024/12/31，河北省生物医药联合基金培育项目，负责人：朱艳艳，15万。

14.功能化COFs抑制β-淀粉样蛋白寡聚化治疗阿尔茨海默病的研究（226Z2601G），2022/01/01-2024/12/31，河北省科技厅中央引导地方科技发展资金项目，负责人：李蒙，15万。

15.基于超分子策略的单相“复方”葛根素降糖药物的构筑、评价及协同机制研究（H2021206101），2021/01/01-2024/12/31，河北省生物医药联合基金培育项目，负责人：郭伟，15万。

16.基于线粒体靶向及联合给药策略的化疗-光热“多靶标、多模式”药物递送体系研究（H2020206416），2020/09/01-2022/12/31，河北省生物医药联合基金重点项目，负责人：王静，30万。

近三年发表主要论文

2026年：

1.Jie Lv, Shuangling Wang, Haozhe Zhang, Yanhua Zhong, Xinjian Guo, Wei Guo*, Meng Li*, A multifunctional oxidative stress amplifier for synergistic disruption of redox homeostasis and enhanced cancer therapy, Journal of Colloid and Interface Science, 2026, 702, 138870（1区TOP，IF9.7）

2.Xueran Shi, Yingbo Cao, Tiance Gu, Ziyang Jia, Zhuozhe Li, Jing Wang*, Qian Han*, Flexible and microporous porphyrin-confined hydrogel for electrochemiluminescent biosensing application, Sensors and Actuators: B. Chemical, 2026,446, 138678（1区TOP，IF7.7）

3.Cuilu Quan, Peixiao Jiang, Ge Gao*, Zhiyu Wang*, Jing Wang*, Mesoporous silica-coated gold nanorod grafted with cisplatin prodrug on the surface enhances radiotherapy for cervical cancer via triple-strategy approach, Colloids and Surfaces B: Biointerfaces, 2026, 257, 115160. （1区，IF5.6）

2025年：

4.Mo Zhang, Siao Yang, Mengxuan Liu, Yawen Chen, Qingqing Dou, Ruoqing Jia, Wei Chen*, Zhengguo Lin*, Jing Wang*, Changwen Hu, Tungstotellurate(VI)-based nanocomposite inhibits breast cancer proliferation and metastasis by enhancing cuproptosis and apoptosis, Angewandte Chemie-International Edition, 2025, e202514795（1区TOP，IF17）

5.Fan Yu, Mao Huang, Rui Wang, Chun Hao,Yanyan Zhu*，Single-atom ruthenium nanozyme-induced signal amplification strategy in photoelectrochemical aptasensor for ultrasensitive detection of chloramphenicol，Biosensors and Bioelectronics，2025, 268, 116917（1区TOP，IF10.5）

6.Xueran Shi, Yingbo Cao, Lin Cong , Tiance Gu , Jing Wang*, Qian Han*, Novel nanoceria in situ-derived porphyrin heterostructure enhanced electrochemiluminescent and colorimetric dual-mode detection of tetracycline residue in foods, Food Chemistry, 2025, 485,144459（1区TOP，IF9.8）

7.Xiaoyu Wang, Chunzhe Xu, Hantao Tian, Yu Pang, Jie Lv*, Meng Li*, FeS embedded bioreactor collaborate with artesunate for cascade-catalytic tumor ferroptosis, Journal of Colloid and Interface Science, 2025, 692, 137479（1区TOP，IF9.7）

8.Mo Zhang, Qingqing Dou, Ge Gao, Fan Xu, Siao Yang, Hongjin Lv*, Jing Wang*, A dual-functional polyoxomolybdate@COF nanoplatform for synergistic chemo-photodynamic tumor therapy, Chinese Chemical Letters, 2025, 111953（1区TOP，IF8.9）

9.Saisai Ren, Han Hao, Wei Guo, Mo Zhang, Honglin Feng, Jing Wang*, Metabolomics-driven elucidation of the synergistic therapeutic mechanism of a novel SGLT-2/PPAR-γ dual receptor supramolecular system for treatment diabetes and obesity, Journal of Pharmaceutical Analysis, 2025, 101308（1区TOP，IF8.9）

10.Rui Wang#, Xiaowei Ma#, Eslam M. Hamed, Baoyue Cao, Lin Wang, Sam Fong Yau Li, Yanyan Zhu*, Deciphering of laccase-like activity ruthenium single-atom nanozyme for identification/quantification and remediation of phenolic pollutants, Sensors and Actuators B: Chemical, 2025, 426, 137112（1区TOP，IF7.7）

11.Qian Han,* Xueran Shi, Yingbo Cao, Tiance Gu, Yizhong Shen,* and Jing Wang*, Porphyrin-decorated sodium alginate hydrogel with carbon nanotubes for confinement-enhanced electrochemiluminescence and antibiotic resistance gene detection, Analytical Chemistry, 2025, 97, 14584−14593（1区TOP，IF6.7）

12.Zhaoyang Gan, Chang Liu, Shaopeng Li, Chengda Ju, Sixuan Huo, Jing Wang*, Yulong Lin*. Artesunate loaded core-shell nanoplatform for the chemo-chemodynamic-photothermal synergistic cancer therapy. Colloids and Surfaces B: Biointerfaces, 2025: 114810.（1区，IF5.6）

13.Hantao Tian, Chunzhe Xu, Xiaoyu Wang, Haozhe Zhang, Yanhua Zhong, Ye Zhang, Jie Lv*, Haiyan Wu*, Meng Li*, Near Infrared-Activatable Nanomodulator Enabling Self-Amplifying Calcium Overload and Oxidative Stress for Precision Cancer Therapy, Advanced. Healthcare Material, 2025, e03914（2区TOP，IF9.6）

14.Xiaoxiao Hu, Qingqing Dou, Peixiao Jiang, Mo Zhang*, Jing Wang*, Targeting matrix metalloproteinases activating and indoleamine 2,3-dioxygenase suppression for triple-negative breast cancer multimodal therapy, International Journal of Biological Macromolecules, 2025, 310, 143289（2区TOP，IF8.5）

15.Mao Huang# , Rui Wang# , Fan Yu , Qi Ding* , Yanyan Zhu*, Bimetallic FeCo phosphide-enabled electrochemical sensor for rapid tanshinol quantification in Salvia miltiorrhiza herb at near-neutral condition, Talanta, 2025, 287, 127611（2区TOP，IF6.1）

16.Hailan Jia, Chi Wang, Yan Fu, Yalin Wang, Xiaoyu Zhang, Yuezhou Tang, Jiahao Ding, Kun He, Jing Wang,*, Yanting Shen*, Visualization of mitochondrial molecular dynamics during mitophagy process by label-free surface-enhanced Raman scattering spectroscopy, Analytica Chimica Acta, 2025, 1345,343748（2区TOP，IF6.0）

17.Jie Lv, Chengcai He, Jingcheng Cao, Qiuyan Shuai, Xifang Liu, Meng Li, Yulong Lin. Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fuorescence and oxidase like activity for dual mode detection of acetylcholinesterase and inhibitors screening. Analytical and Bioanalytical Chemistry, 2025, 417:1093–1104（2区，IF3.8）

18.Yuxin Wei, Qingqing Bai, Xinlu Ning, Xiaofan Bai, Jie Lv*, Meng Li*, Covalent organic framework derived single‑atom copper nanozymes for the detection of amyloid‑β peptide and study of amyloidogenesis, Analytical and Bioanalytical Chemistry, 2025, 417, 1081–1092（2区，IF3.8）

19.Jiajun Li,† Sihui Wu,† Xueran Shi, Yingbo Cao, Han Hao, Jing Wang,* and Qian Han*, Machine Learning-Assisted Biomass-Derived Carbon Dots as Fluorescent Sensor Array for Discrimination of Warfarin and Its Metabolites, Langmuir, 2025, 41, 1694−1702（2区，IF3.7）

2024年：

20.Xiaoguang Dai, Zhiwen Liu, Xiaoyi Zhao, Kangli Guo, Xiaokang Ding, Fu-Jian Xu, Nana Zhao*, NIR-II-responsive hybrid system achieves cascade-augmented antitumor immunity via genetic engineering of both bacteria and tumor cells. Advanced Materials, 2024, 36, 2407927（1区TOP，IF27.4）

21.Xiaoxiao Hu, Mo Zhang*, Cuilu Quan, Saisai Ren, Wei Chen*, Jing Wang*, ROS-responsive and triple-synergistic mitochondria-targeted polymer micelles for efficient induction of ICD in tumor therapeutics, Bioactive Materials, 2024, 36, 490–507（1区TOP，IF20.3）

22.Du Sifan, Jiang Yuqian, Jiang Hejin, Zhang Li,* Liu Minghua,* Pathway-dependent self-assembly for control over helical nanostructures and topochemical photopolymerization. Angewandte Chemie-International Edition. 2024, 63, e202316863. (1区TOP，IF: 16.1)

23.Zhang Qi, Jia Hailan, Chen, Dongxue ; Wang, Song; Ju, Guannan, Zhang, Lina*. Protease-activatable nanoprobe based on peptide decorated titanium carbide engineering for synchronous monitoring of cancer biomarkers with different spatial distributions, Chemical Engineering Journal, 2024, 502: 157896.（1区TOP，IF13.2）

24.Yu Pang, Jie Lv, Chengcai He, Chengda Ju, Yulong Lin, Cong Zhang*, Meng Li*，Covalent organic frameworks-derived carbon nanospheres based nanoplatform for tumor specific synergistic therapy via oxidative stress amplification and calcium overload，Journal of Colloid and Interface Science，2024, 661, 908–922（1区TOP，IF9.7）

25.Kai Kang, Hui Zhang, Licong Jia, Xiaoxin Tan, Beibei Wang, Xiang Gao, Yan Fu, Lingmei Niu*, Xueping Ji*, Enhanced sensitivity for Aflatoxin B1 detection in food through a h-Zn1Cd5S-based photoelectrochemical aptasensor, Sensors and Actuators: B. Chemical, 2024, 413, 135894（1区TOP，IF7.7）

26.Zhang Lina*, Zhang Q, Chen D, You mei Deng, Ruoxi Wang, Song Wang*. Titanium carbide-based spatiotemporally selectable-activated entropy-driven DNA nanoplatform for amplified microRNA imaging and photothermal therapy in vivo. Analytical Chemistry, 2024, 96(40): 16036-16044.（1区TOP，IF6.7）

27.Qian Han, Na Wang, Mengfan Wang, Jing Wang*, Silver nanoparticles in situ enhanced electrochemiluminescence of the porphyrin organic matrix for highly sensitive and rapid monitoring of tetracycline residues, Journal Of Agricultural And Food Chemistry, 2024, 72, 16, 9498–9506（1区TOP，IF6.2）

28.Siao Yang, Xiaoxiao Hu, Zhengze Yong, Qingqing Dou, Cuilu Quan, Hongbo Cheng, Mo Zhang*, Jing Wang*, GSH-responsive bithiophene Aza-BODIPY@HMON nanoplatform for achieving triple-synergistic photoimmunotherapy, Colloids and Surfaces B: Biointerfaces, 2024, 242, 114109（1区，IF5.6）

29.Shuangling Wang, Yalin Wang, Jie Lv, Chunzhe Xu, Yuxin Wei, Guiying Wang,*and Meng Li*, Remote manipulation of TRPV1 signaling by near-infrared light-triggered nitric oxide nanogenerators for specific cancer therapy, Advanced Healthcare Materials, 2024, 2303579（2区TOP，IF9.6）

30.Yao Zhang#, Mo Zhang#, Xiaoxiao Hu, Han Hao, Cuilu Quan, Tiantian Ren,Huile Gao*, Jing Wang*, Engineering a porphyrin COFs encapsulated by hyaluronic acid tumor-targeted nanoplatform for sequential chemo-photodynamic multimodal tumor therapy, International Journal of Biological Macromolecules, 2024, 279, 135328（2区TOP，IF8.5）

31.Mi Wang,Mo Zhang,Jianyi Bi, Jincan Li, Xiaoxiao Hu, Lina Zhang, Yao Zhang, Wenli Wang, Yuan Lin, Hong-Bo Cheng, and Jing Wang*, Mitochondrial targeted thermosensitive nanocarrier for near infrared-triggered precise synergetic photothermal nitricoxide chemotherapy, ACS Applied Materials & Interfaces, 2024,16,18252−18267 （2区TOP，IF8.2）

32.HanHao, Tiantian Ren, Cuilu Quan, Jing Wang*, Chiral 5-fluorouracil-arginine cocrystals screened by wet powder grinding method: Leading to synergistic anti-tumor and alleviate cardiotoxicity, Powder Technology, 2024, 436, 119487（2区，IF4.6）

33.Han Hao, Tiantian Ren, Cuilu Quan, Wei Guo, Jing Wang*, Selective pharmaceutical sensitization design based on amino acid metabolism: 5-fluorouracil-sarcosine cocrystal prepared by wet powder grinding method, Advanced Powder Technology, 2024, 35, 104514（2区，IF4.2）

2023年：

34.Shuangling Wang, Yu Pang, Shuyang Hu, Jie Lv, Yulong Lin, Meng Li*. Copper sulfide engineered covalent organic frameworks for pH-responsive chemo/photothermal/chemodynamic synergistic therapy against cancer. Chemical Engineering Journal, 2023, 451:138864（1区TOP，IF13.2）

35.Jie Lv, Xiaoyu Wang, Xue Zhang, Runpei Xu, Shuyang Hu, Shuangling Wang, Meng Li*, Tumor microenvironment-responsive artesunate loaded Z-scheme heterostructures for synergistic photo-chemodynamic therapy of hypoxic tumor, Asian Journal of Pharmaceutical Sciences. 2023, 18(3), 100798（1区TOP，IF11.9）

36.Du Sifan, Wang Yuan, Wang Fulin, Wang Tianyu,* Zhang Li,* Liu Minghua*, Evolution of hollow nanosphere to microtube in the self-assembly of chiral dansyl derivatives and inversed circularly polarized luminescence. Chinese Chemical Letter. 2023, 35, 109256(1区TOP，IF9.4)

37.Mo Zhang, Zheng Li, Yeqin Feng, Xing Xin, Guo-Yu Yang*, Hongjin Lv*，Highly selective hydrogenolysis of lignin β-O-4 models by a coupled polyoxometalate/CdS photocatalytic system, Green Chemistry, 2023,25, 10091-10100（1区TOP，IF9.2）

38.Qian Han, Xueran Shi, Kai Kang, Yingbo Cao, Lin Cong, and Jing Wang*, Donor-acceptor based enhanced electrochemiluminescence of coumarin microcrystals: Mechanism study and sensing application, Sensors&Actuators:B.Chemical, 2023, l393, 134296（1区TOP，IF7.7）

39.Shuyang Hu, Xinlu Ning, Jie Lv, Yuxin Wea, Huiran Zhang*, Meng Li*, Enantioselective modulation of amyloid burden and memory deficits by chiral polyoxometalates for Alzheimer’s disease treatment, Inorganic Chemistry Frontiers, 2023, 10, 5347-5356（1区，IF6.4）

40.Yanting Shen*, Zhichuan Xin, Xintong Pan, Yao Zhang, Hailan Jia, Xuerui Fu, Jing Wang*, Multifunctional fluorescent mesoporous carbon nanoprobe for MMP-2-activated cancer cell imaging and targeted photothermal therapy, Analytica Chimica Acta, 2023, 1260, 341203（2区TOP，IF6.0）

41.Xiaoxiao Hu, Lina Zhang, Wenli Wang, Yao Zhang, Jing Wang*, Mitochondria-targeted and multistage synergistic ROS-elevated drug delivery system based on surface decorated MnO2 with CeO2 for enhanced chemodynamic/chemotherapy, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 656, 130495（2区，IF5.4）

42.Hu Xiaoxiao, Quan Cuilu, Ren Tiantian, Zhao Linan, Shen, Yanting, Zhu Yanyan, Wang, Jing*, MnO2 nanoparticles decorated with Ag/Au nanotags for label-based SERS determination of cellular glutathione，Microchimica Acta，2023，190, 341（2区，IF5.3）

43.Yanyan Zhu*, Kai Kang, Juan Jia, Sen Wang*, Jing Wang*, Insights into the enhanced electrochemical  sensing behavior of hydroquinone and catechol  simultaneously enabled by ultrafine layer CoP–NiCoP heterostructure on graphene frameworks, Nanoscale, 2023, 15, 9823-9834（2区，IF5.1）

44.Xiaowei Ma, Mao Huang, Juan Jia, Han Wang, Jing Wang*, Yanyan Zhu*, Tuning pore structure and specific surface area of graphene frameworks via one-step fast pyrolysis strategy: Impact on electrochemical sensing behavior of catechol, Microchemical Journal, 2023, 187, 108441（2区，IF5.1）

45.Wei Guo, Xueqing Dong, Yuanchun Li, Congwei Li, Yawen Tian, Huibing Gao, Tiantian Li, Hanruo Zhu, Jing Wang*, Caiqin Yang*, Co-amorphous formulation of dipyridamole with p-hydroxybenzoic acid: Underlying molecular mechanisms, physical stability, dissolution behavior and pharmacokinetic study, European Journal of Pharmaceutics and Biopharmaceutics, 2023,184, 139–149（2区，IF4.3）

46.Wang, Mi，Zhang, Mo，Hu, Xiaoxiao，Wang, Wenli，Zhang, Yao，Zhang, Lina，Wang, Jing*, Lipid-functionalized gold nanorods with plug-to-direct mitochondria targeting ligand for synergetic photothermal-chemotherapy of tumor therapy, European Journal of Pharmaceutics and Biopharmaceutics, 2023, 185, 71–81（2区，IF4.3）

47.Han Hao, Yao Zhang, Xiaoxiao Hu, Wei Guo, Caiqin Yang, Jing Wang*, Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration, European Journal of Pharmaceutics and Biopharmaceutics, 2023, 187, 12-23（2区，IF4.3）