赵伟欣博士-副教授
发布时间：2019-07-30 浏览次数：0次
赵伟欣 河北医科大学，药理学教研室，讲师
主要研究方向：
疼痛发生机制，短肽类药物研发
科研项目：
1.“靶向EGFR膜外段结构域的新型短肽类抑制剂设计和分子机制研究（8200131494）”国家自然科学基金青年科学基金项目（2021.01-2023.12）主持
2.“基于小分子半抗原融合的EGFR膜外段抑制剂的设计及分子机制研究 （H2022206174）”河北省自然科学基金青年科学基金项目（2022.01-2024.12）主持
3.“外周感觉神经节内十八烷神经肽对GABAA受体的调节机制及其对慢性疼痛的治疗意义（CYQD2023004）” 河北医科大学春雨计划启动基金项目（2023.01-2024.12）主持
4.“DRG内地西泮结合抑制剂(DBI)调控GABAA受体的分子机制研究(BJK2024005)” 河北省教育厅青年拔尖人才计划项目（2023.01-2024.12）主持
5.“DRG内地西泮结合抑制剂调控 GABAA 受体的分子机制研究及新型短肽类镇痛药物的设计”河北省燕赵黄金台聚才计划骨干人才项目（2025.01-2027.12）主持
论文情况：
(1) Weixin Zhao, Liming Liu*, Guocheng Du, Song Liu*.A multifunctional tag with the ability to benefit the expression, purification, thermostability and activity of recombinant proteins. Journal of Biotechnology, 2018, 283:1-10.
(2) Weixin Zhao, Guocheng Du, Song Liu*. An efficient thermostabilization strategy based on self-assembling amphipathic peptides for fusion tags. Enzyme and Microbial Technology, 2019, 121:68-77.
(3) Weixin Zhao, Song Liu*, Guocheng Du. An expression tag library based on self-assembling amphipathic peptides for overproduction of recombinant proteins. Microbial Cell Factory, 2019, 18:91.
(4) Weixin Zhao, Yixiao Yan, Zhongqing Xiao, Meihong Wang, Mingjiang Xu, Zhe Wang, Yi Wang, Zaizhou Zhuang, Daona Yang, Gaozhi Chen*, Guang Liang*. Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-KB signaling pathways. Biomedicine & Pharmacotherapy, 2021, 141: 111874.
(5) Weixin Zhao, Jie Ruan, Qingyan Wang, Guocheng Du, Song Liu*. Metabolic pathway optimization through fusion with self-assembling amphipathic peptides. Process Biochemistry. 2021, 100: 117-123.
(6) Xiaohui Li, Haiyan Liu, Shengjie Ding, Ziyu Tian, Jia Song, Huayu Zhong, Luwei Fu, Xiaojun Cai, Fengyu Huang, Kun Wang, Lilong Dong, Weixin Zhao*, Yuepiao Cai*, and Shijie Dai*. Chemoenzymatic Synthesis of DNP-Functionalized FGFR1-Binding Peptides as Novel Peptidomimetic Immunotherapeutics for Treating Lung Cancer. Journal of Medicinal Chemistry. 2024: Volume 67/Issue 17.
(7) Weixin Zhao, Mengyu Chen, Xialin Yu, Huayu Zhong, Shikang Hao, Shuangyu Liu, Ziyu Tian, Lilong Dong, Shijie Dai*, Haiyan Liu*, Han Hao*. 4-Methylesculetin attenuates inflammatory pain via inhibition of Sp1-TRPV1 and inflammation related signaling pathways. International Immunopharmacology. Volume 152, 16 April 2025, 114379.
授权发明专利：
1. Liu Song; Zhao Weixin; Chen Jian; Du Guocheng; A multi-functional peptide for expression, purification, and stabilization of recombinant proteins, April 30, 2019, United States Patent, 10273266 (专利)
2. Liu Song; Chen Jian; Du Guocheng; Zhao Weixin; An asparaginase mutant with efficient expression, activity and stability, July 2, 2019, United States Patent, 15658193 (专利)
3.刘松；陈坚；堵国成；赵伟欣；一种自组装双亲短肽及其应用，2020-03-06，中国，CN106986922B (专利)
4.赵伟欣; 董立龙; 杜肖娜; 陈梦雨; 于夏琳; 郝瀚; 陆洋; 王苗苗；一种具有镇痛活性的GABA-A受体的靶向肽DZ2及其合成方法与应用，2024-07-05，中国，CN118290538A